acupuncture animal research

Electroacupuncture at GB20 Relieves Migraine and Lowers CGRP in Animals

By | June 17th, 2017|Acupuncture research, Autonomic Nervous System|

I was not aware that migraine sufferers had cutaneous allodynia.  That may account for the exaggerated autonomic response to needling I've noticed in the clinic. Neural Regen Res. 2017 May;12(5):804-811. doi: 10.4103/1673-5374.206652. Electroacupuncture at Fengchi (GB20) inhibits calcitonin gene-related peptide expression in the trigeminovascular system of a rat model of migraine. Zhao LP1,2, Liu L1, [...]

Comments Off on Electroacupuncture at GB20 Relieves Migraine and Lowers CGRP in Animals

Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.

By | March 19th, 2017|Acupuncture research, Autonomic Nervous System|

Ancient Medicine Made Modern This study with a million authors is maily out of Florida.  It's pertinent for a variety of reasons.  There is the remarkable fact that this huge group was able to get funding for such sophisticated acupuncture research and that it paid off.  Way cool on all counts. Unfortunately, no [...]

Comments Off on Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.

Electroacupuncture for Constipation: Animal Study

By | February 11th, 2017|Acupuncture research, Autonomic Nervous System, Benefits|

Ancient Wisdom Through the Ages   I see the problem of constipation quite a bit in the clinic, so I'm glad to have this reference.  Stim was at 2 to 15 hz. BMC Complement Altern Med. 2016 Oct 18;16(1):392. Electroacupuncture at acupoint ST 37(Shangjuxu) improves function of the enteric nervous system in a [...]

Comments Off on Electroacupuncture for Constipation: Animal Study

Electroacupuncture at Ipsilateral or Contralateral ST36-ST37 Acupoints on Inflammatory Pain.

By | February 9th, 2017|Acupuncture research|

Ancient Medicine Made Modern Patients often wonder why I treat both sides (Right and Left) in musculoskeletal conditions.  This has long been a trick in Chinese Medicine, particularly if the inflamed joint is very sensitive, or in a cast and it often works great.  The study below shows, perhaps, why.  It's overall reduction [...]

Comments Off on Electroacupuncture at Ipsilateral or Contralateral ST36-ST37 Acupoints on Inflammatory Pain.

Electroacupuncture Improves HPAA axis in animals

By | January 28th, 2017|Acupuncture research, Autonomic Nervous System, Stress|

https://www.ncbi.nlm.nih.gov/pubmed/26573696 Neuromodulation. 2016 Jul;19(5):498-506. doi: 10.1111/ner.12366. Epub 2015 Nov 16. Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats. Zhu J1, Chen Z1, Zhu L1, Meng Z1, Wu G1, Tian Z1. Author information Abstract OBJECTIVE: The study aims to know the effect of electroacupuncture (EA) in maintenance of [...]

Comments Off on Electroacupuncture Improves HPAA axis in animals

Electro Acupuncture Improves Gastric Motility Through Vagal Activity

By | December 17th, 2016|Acupuncture research, Autonomic Nervous System, Stress|

Ancient Medicine Made Modern One more strategy to implement and study in the quest for vagal enhancement! Discussion of a similar strategy here using abdominal points Liv13, Liv14 and abdominal GB points. World J Gastroenterol. 2015 Dec 28;21(48):13480-9. Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic [...]

Comments Off on Electro Acupuncture Improves Gastric Motility Through Vagal Activity

Research Casting Doubt on Acupuncture

By | July 30th, 2016|Acupuncture research, Big Pharma, First Do No Harm: Risks, Follow the Money|

Through some web searching, I was able to find a copy of this paper that's not behind a subscription firewall. These kinds of papers have been coming out for decades.  It's a safe bet as a journalist to criticize acupuncture, it's a kiss up kick down, comforting the comfortable gambit. There are no heavy hitters [...]

Brain Physiology Behind Electroacupuncture’s Modulating Effect on Blood Pressure

By | May 25th, 2016|Acupuncture research, Autonomic Nervous System|

Nice.  This article appears in Nature, quite a coup. There is a lot about this paper that surprises me.  Perhaps I'm just not familiar enough with this type of experimental set up, and haven't been aware of these studies.   What they found was that naloxone interfered with the suppression of blood pressure by electroacupuncture [...]

Electroacupuncture and PCOS effects

By | May 16th, 2015|Acupuncture research, Autonomic Nervous System|

Ancient Medicine Made Modern This is a complicated/detailed study of the effects of electroacupuncture and manual acupuncture on a PCOS rat model.  The details are way over my head, but it seems that the acupuncture effects are not necessarily achieved through the sympathetic nervous system.  Of great interest to me since the autonomic [...]

Bee Venom and the Anti-inflammatory Response

By | March 21st, 2015|Acupuncture research, Autonomic Nervous System, Heart Rate Variability|

Ancient Medicine Made Modern The article below.is related to the previous blog post about vagal stimulation leading to decreased inflammation.  The use of bee venom may be a more elegant and cheaper solution.  Probably why it won't gain much industry interest.  I would love to be able to study this technique in conjunction [...]

Electroacupuncture ST36 prevents postoperative intra-abdominal adhesions formation.

By | January 28th, 2015|Acupuncture research, Autonomic Nervous System, Heart Rate Variability|

Ancient Wisdom Through the Ages Fascinating study that shows electroacupuncture at St36 can reduce postoperative adhesions by anti-inflammatory cholinergic effects.   Sham acupuncture does not have the same effect.  Vagotomy reduces this effect.  So somehow St36 has vagal enhancing characteristics. This is a key point for me since vagal tone is, to a [...]

Electrical Ear Stim leads to Smaller Infarct Size in Rats

By | January 14th, 2015|Acupuncture research|

This is of interest since my recent bedside research has been looking at the effects of ear stim on the last 5 minutes of acupuncture treatment.  In general, I do see a decrease in LF/HF, or decrease in stress response with ear stim. Bain Stimul. 2015 Jan-Feb;8(1):7-12. doi: 10.1016/j.brs.2014.09.009. Epub 2014 Sep 28. Electrical Stimulation [...]

Acupuncture 2 Hz and 100 Hz effects on fMRI default mode

By | December 20th, 2014|Acupuncture research|

Ancient Wisdom Through the Ages This article show different effects of electroacupuncture depending on the frequency used.  It also shows that this effect takes 20 minutes to develop.  I'm focusing quite a bit on what happens within an individual acupuncture treatment with HRV, and find that usually the autonomic response is going back [...]

Variation of Stimulation Intensity and Neural REgulation in Mirror Image pain

By | September 20th, 2014|Acupuncture research|

This article looks at two levels of manual stimulation on GB 30 in rats with in a neuropathic pain model.  They find no difference to the control in mild stimulation, but they do see an up regulation in the strong stimulation group. Zhen Ci Yan Jiu. 2014 Apr;39(2):106-11. [Effect of mild and strong manual acupuncture [...]

Effect of acupoint catgut-embedding therapy on changes of structure of hippocampal neurons in senile chronic stress rats

By | May 31st, 2014|Acupuncture research, Autonomic Nervous System, Stress|

Ancient Wisdom Through the Ages This study ambitiously explores catgut-embedding for the havoc wrought by stress on senility.  One of Sapolsky's key findings was that stress causes a feed forward loop on the hippocampus during senility.  The altered hippocampus then causes more stress, which then leads to more senility.  This is a particular [...]

Acupuncture for Sepsis and Immune Enhancement

By | March 16th, 2014|Acupuncture research|

Use Antibiotics Judiciously! This is a report on a recent lab study on mice where sepsis (life threatening, whole body infection) was induced.  But it adds to the weight of evidence and does mention the role of the vagus, the focus of my research.  This study also emphasized the role of intact adrenal glands. It also [...]

Low Frequency Transcutaneous Electrostimulation More Effective on Opiate Receptors in Animal Studies

By | February 5th, 2014|Acupuncture research|

Ancient Wisdom Through the Ages Low frequency acupuncture better than high frequency for pain in animal study.  Interesting since there has been a lot of research on the different opiate receptors involved in 2Hz versys 100 hz.  Maybe bogus?  Maybe not? J Neurosci Res. 2014 Jan 31. doi: 10.1002/jnr.23351. [Epub ahead of print] [...]

Acupuncture Mechanisms for Pain: from Anesthesiology Journal

By | December 20th, 2013|Acupuncture research, First Do No Harm: Risks|

Pain hurts. Concise summary of the current science behind acupuncture's pain relieving effects, and a definitive endorsement for its use to minimize potentially dangerous pharmaceuticals. Anesthesiology. 2013 Dec 9. [Epub ahead of print] Mechanisms of Acupuncture-Electroacupuncture on Persistent Pain. Zhang R, Lao L, Ren K, Berman BM. Source From the Center for Integrative [...]

Auricular acupunture for seizures: Animal Study

By | November 5th, 2013|Acupuncture research, Autonomic Nervous System|

This article is of interest because of the vagal activation incurred by auricular acupuncture.  I should use/study it more.  Too many projects... Full article here. BMC Neurosci. 2013 Aug 9;14:85. doi: 10.1186/1471-2202-14-85. The auriculo-vagal afferent pathway and its role in seizure suppression in rats. He W, Jing XH, Zhu B, Zhu XL, Li L, Bai [...]

Nerve Growth Factor and Dementia: Acupuncture Effects

By | July 1st, 2013|Acupuncture research, Acupuncture Research 2, uncategorized|

This is from the lab of Manni et al.  I've been following his work for awhile because of his work on allergies and acupuncture. My previous post discussed his approach to the topic, also involving Nerve Growth Factor (NGF.) J Alzheimers Dis. 2013;33(3):767-73. doi: 10.3233/JAD-2012-121309. Brain cholinergic markers and Tau phosphorylation are altered in experimental [...]

Acupuncture and HRV in Beagles

By | April 28th, 2013|Acupuncture research, Acupuncture Research 2, Autonomic Nervous System, Heart Rate Variability|

They really were careful to only use 3 dogs.  This is a collaborative study between China and Austria as is typical of the Litscher group. This is a good example of why this works so well.  In China they are able to get around animal issues easier... Free article here. Their results are pretty interesting [...]

Cardiovascular Depressor Response: Longhurst Brain Study

By | April 28th, 2013|Acupuncture research, Acupuncture Research 2, Autonomic Nervous System|

Blog has been quiet since I was overseas after attending and presenting at the SAR conference in Ann Arbor.  It was a pretty good conference.  No big breakthroughs yet, unfortunately, but incremental progress with brain mapping.  An interesting forum discussion on electroacupuncture versus manual acupuncture.  The upshot was that we don't have enough evidence yet.  [...]