A review article from China. Good stuff! Plus free full text link below.
Substantial evidence has shown that the skin is a neuroimmunoendocrine organ; the body skin is rich in nervous, endocrine, immune tissues structurally, and closely associated with these three systems in function. And exogenous noxious stimuli to the skin can affect the NEI network through several pathways,5 which provides beneficial evidences for the exogenous noxious stimuli activating the NEI network.